prostate cancer metastasis

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Q: Prostate Cancer Bone Metastasis – Testosterone, DHEA Progesterone, Estriol Supplementation?
There seem to be two views points on Testosterone and DHEA:

(a) Testosterstone and DHEA Supplementation can worsen prostate cancer.
(b) Testerstone harms only at less less than adequate levels (whose T levels are stuck in the middle – less than nomal but not minimal). Both in very low levels and at high levels these harmones will help in combating cancer.

We know that in majority of cases Testosterone blockade helps control the disease.

There is some anecdotal (http://www.mercola.com/1998/archive/natural_progesterone2.htm) evidence that Progesterone local application has benefitted advanced prostate metastasis.

Has any research been done with Testosterone/DHEA Progesterone supplements on Advanced PCa persons.

I am interested to know if anyone with advanced Prostate malignancy or breast malignancy on the bone has tried DHEA and/or Testosterone, Progesterone, Estriol supplementation and has perceived benefits.

Accurate info will be of great relevance.

Sammy

A: For a fact, testosterone supplementation will worsen prostate cancer

I don’t know if DHEA supplementation or HGH injections will worsen prostate cancer. If anybody knows, I am interested in the answer myself. Please reply to this question. It is a good one. Reply to this posting and to allanbrandt@yahoo.com

Androgen depravation using Lupron or castration is first line treatment of prostate cancer if it has spread, even if it has spread to the bone. If that is not enough, sometimes they will add a second line hormonal treatment such as high dose Ketoconazol to quickly lower your testosterone level to almost zero, but monitor weekly for liver damage using high dose Ketoconazol. (I learned this the hard way). Usually there is a response from the above treatments, but only temporarily.

Estrogen based treatments such as Megace which contains progesterone, or DES which contains estrogen, are not effective treatments if prostate cancer is already in the bone. Estriol supplementation may be similar. Not effective but cant hurt. Prostate cancer hates all female hormones.

Q: PSA and Tumor Markers for Prostate Bone Metastasis?
This message pertains to the utility of Prostate Specific Antigen (PSA), for the treatment of Advanced Prostate Cancer.

PSA writes Dr. John Lee (Harmone Balance for Men) is produced both within the Prostate Gland and the Breast Tissue. He further writes that the normal cells produce PSA, an anti angiogenesis defence when there are abnormally growing cells in the prostate. This seems to indicate that the PSA has no correlation with what is happening in the bone and anywhere outside prostate. Is this correct?

There are further questions:

(a) How do we monitor bone metastasis and other situations where the cancer has escaped out of prostate. (non-Bone Scan/MRI options)

(b) Are there other prostate tumor markers that can tell us the tumor loads/tumor activity in non prostate areas such as the bones.

(c) Will Acid Phosphatase levels inform us the status of prostate metastasis on bone.

(d) Are Osteoblastic/Osteocystic/Osteocytic rates right parameters to track.

Sam

A: There are a few misconceptions here.

* PSA is manufactured almost exclusively by prostate cells. Although there are a few other cell types that can make minute quantities of it, their contribution is so small that PSA is indeed, for all practical purposes, a prostate-_specific_ marker.
However, that doesn’t mean it measures only cells that reside in the prostate gland.

* In a person with normal prostatic health, prostate cells reside only in the prostate gland. But in a person with advanced prostate cancer, most of his prostate cells have traveled to areas outside the prostate, typically the bones and lungs.

Therefore, for men with advanced prostate cancer, PSA is normally the single best way of tracking the cancer, since it correlates so well with the number of prostate cells in the body — both within the gland (if it’s still there) and outside the gland, and thus presumably cancerous.

(a) To specifically find bone metastases, one would normally use an imaging technique, such as a bone scan, a CT scan, and/or a PET scan (preferably one that uses 11C-choline rather than 18F-FDG). It’s unclear why someone would try to monitor bone metastasis without any attempt to image the bones, so I don’t know what prompts the question. (Not all imaging techniques use radioactive tracers, for example. And if expense is an issue, then maybe consider simple X-rays.)

(b) There are indeed other tumor markers, but none of them are specific to rogue prostate cells that are in the _bones_, as opposed to rogue prostate cells generally. Such tumor markers include: PSMA, PAP, NSE, CGA, and CEA.

(c) Yes and no. PAP (prostatic acid phosphatase) is useful as a tumor marker, but no tumor marker, so far as I know, can possibly differentiate betwee bone and non-bone metastasis.

(d) Yes and no. If you’re focusing only on the bone, then you are interested in overall rates of bone-building (osteoblastic) and bone-resorption (osteoclastic) activity. But you won’t know _where_ the activity is occurring.

Most importantly: In a person has advanced prostate cancer, bone issues are one of the consequences. But it’s much more important to tend to the cancer itself than to focus on only one of its consequences. If a car is heading downhill and its brakes are failing, one of the consequences will be tiretread left on the roadway. Rather than trying to measure and track the tiretread, it’s more important to find a turnoff, or a soft ditch, or (best) an alternate braking system.

Good luck!
(BTW, I’m now also a member of the PCa tribe.)

Q: Cancer deaths usually result from metastasis?
Unless the primary site of the cancer is a vital organ such as liver or lung, are most cancer deaths caused by the metastasis to vital organs? What I mean is, if you have a cancer of the breast/tongue/ovary/prostate… ALONE that has not spread to other organs, then you don’t die from it. (But yes, I know cancer eventually always spread and metastasizes.)

A: According to an article, “Metastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients.”

http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=OCL2005069S01014

Q: Questions about prostate cancer?
As my father was diagnosed with PC (75 yo, gleason 8, psa 11, stage T2b)I wanted to help him as he doesn’t have any access to the Internet. After 2 months of searching I can now say that I’m quite good informed about the disease, the treatments etc. But I still have some critical questions: what is the turning point, after which this “mild” form of cancer turns into an agressive one and kills the patient? Does it happen after it escapes from the gland and causes metastases? Does it always escape from the capsule and treatment(any treatment) tries to keep it there as long as possible? I would very much appreciate if someone could answer these questions.

A: Prostate cancer is one of the most “curable” forms of cancer. many men live for years with it. overall there is a disease free survival rate of 70-85% for 5 years and a 45-75% for 10 years. most men diagnosed with prostate cancer are over age 65 and have other health issues. many men will die WITH prostate cancer but not BECAUSE of prostate cancer.
the gleason score correlates closely with the prognosis.
a gleason score over 8 and staging of T3-T4 is considered advanced stage disease.
a gleason score of 8-10 is a moderately invasive cancer and more prone to metastisize. it is also usually faster growing than lower gleason score tumors. but the T2b means that the cancer is contained within the prostate and has not spread-and hopefully with treatment it won’t. prostate cancer does not always escape from the capsule or metastisize. it does not suddenly turn aggressive and “kill” the patient.

The treatments are designed to kill the cancer cells. (except surgical removal of the prostate) It’s not about trying to keep the cancer encapsulated but getting rid of it. cancer cells are mutations and as such any damage to them from treatments will disable them from reproducing. the healthy cells are effected by the treatments as well but because they are normal cells they can repair themselves and replicate. as the cancer cells die off, the healthy cells reproduce and take their place. usually after treatments, the persons psa will go way down. i don’t know what type of treatment your father is having but i do know that they are all very effective. there have been a lot of studies on prostate cancer and it is one of the cancers that is understood better than some others. if the cancer metastisizes then it becomes more serious but as of now, your father does not have any mets-so that is a good thing.
i am a radiation therapist and about half my patients are being treated for prostate cancer with very good results. and by the way they all do not lose their manly manhood! hope this info helps. good-luck to you and your father.

Q: Hi..is Gleason IV prostate adenocarcinoma be treated? if it’s not . can u tell me the life span of the patient
my father is diagnosed with Gleason IV adenocarcinoma of the prostate with slight bone metastases to ischium and L11-L12 vertebrea.. i want to know if there is any effective treatment for this type of cancer. He underwent bilateral orchiectomy and is taking bicalutamide tablets (50 mg)… He also had an injection of zoledronic acid 4 mg

I want to know if these treatments are the best available.

OR
Sir, is it not treatable.. if it, can u tell me the life span..

We are all worried, plz reply as soon as possible

A: My husband has the same cancer as your father, but I think his might be more advanced that your dad’s. My husband is 63 years old. He is taking the same treatments as your dad, but also a bone strengthener intravenously once every 4 weeks. The bone strengthener is called Zometa, and this treatment takes about 30 minutes each time. He also had 5 radiation treatments to his spine which helped greatly with pain control.

Once cancer has spread beyond the prostate it can’t be cured, but it can often be controlled for several years. It sounds like my husband has many more spots of cancer in his bones than your dad does, and we are hopeful that he will have at least a few years. The most important thing for your dad is to not break a bone – cancer in the bones makes them very brittle. In addition to the intravenous bone strengtheners my husband takes calcium and Vitamin D every day – prescribed by the cancer specialist. He takes very strong pain meds also.

The day will come when the hormone treatments will stop working. When that happens there is some research that suggests some chemotherapy drugs can give the person a few more months of life. The overall life expectancy at this stage tends to be up to three years, but every individual is different and responds differently to treatment. It will be affected by your dad’s health otherwise, his strength in fighting this, his attitude, and his will to live.

Be strong yourselves and take care of yourselves. You need to take care of you in order to help him. I have learned that. It sounds like he is getting good care. Ask about the need for bone strengtheners. Also, good nutrition is very important in figthing cancer. Make sure he eats a healthy diet, low in fat particularly. Try to keep a positive outlook, and now is the time to live each day as if it is your last. Life becomes precious when we realize it is on a timer. Take care, and God bless.

Q: Your thoughts on humanity?
Human Is the general name for a group of more than 100 nations in which individuals in a part of the world begin to grow out of control. Although there are many kinds of humans, they all start because flawed individuals grow out of control. Unaware Human can cause serious illness and even death.

The world is made up of hundreds of millions of living individuals. Natural world individuals grow, populate, and die in an orderly fashion. During the early years of a species’s life, natural individuals populate faster to allow the species to grow. After the species becomes an adult, most individuals populate only to replace worn-out or dying individuals or to repair injuries.

Human starts when individuals in a part of the world start to grow out of control. There are many kinds of Human, but they all start because of out-of-control growth of flawed individuals.

Human individual growth is different from natural individual growth. Instead of dying, Human individuals continue to grow and form new, flawed individuals. Human individuals can also invade (grow into) other habitats, something that natural individuals cannot do. Growing out of control and invading other habitats are what makes a individual a Human individual.

Individuals become Human individuals because of damage to The Brain. The Brain is in every individual and directs all its actions. In a natural individual, when The Brain gets damaged the individual either repairs the damage or the individual dies. In Human individuals, the damaged The Brain is not repaired, but the individual doesn’t die like it should. Instead, this individual goes on making new individuals that the world does not need. These new individuals will all have the same damaged The Brain as the first individual does.

In most cases the Human individuals form a city. Some Humans, like leukemia, rarely form cities. Instead, these Human individuals involve the blood and blood-forming organs and circulate through other habitats where they grow.

Human individuals often travel to other parts of the world, where they begin to grow and form new cities that replace natural tissue. This process is called metastasis. It happens when the Human individuals get into the bloodstream or lymph vessels of our world.

No matter where a Human may spread, it is always named for the place where it started. For example, breast Human that has spread to the liver is still called breast Human, not liver Human. Likewise, prostate Human that has spread to the bone is metastatic prostate Human, not bone Human.

Different types of Human can behave very differently. For example, lung Human and breast Human Is very different nations. They grow at different rates and respond to different treatments. That is why populations with Human need treatment that is aimed at their particular kind of Human.

Today, millions of populations are living with Human or have had Human. The risk of developing most types of Human can be reduced by changes in a species’s lifestyle, for example, by quitting smoking, limiting time in the sun, being physically active, and eating a better diet. The sooner a Human Is found and treated, the better the chances are for living for many years.

Source: http://www.cancer.org/Cancer/CancerBasics/what-is-cancer

Replaced Words:
Cancer = Human
cells = Individuals
cell = individual
Body = World
abnormal = flawed
untreated = unaware
normal = natural
diseases = nations
person = species
tissues = habitats
DNA = the brain
tumor = city
tumors = cities
people = populations
divide = populate

A: That is one of the many ways to look at it.

A very stunted negative way but it is a way.

Love and blessings Don

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